49ers' Mostert (ankle) ruled out against Saints

5:25 PM ET

SANTA CLARA, Calif. — Heading into their weekend off after a Thursday night loss to the Green Bay Packers, the San Francisco 49ers held out at least some hope that offensive reinforcements would be on the way back from injury.

That help will have to wait at least another couple of weeks. The Niners will once again be without running back Raheem Mostert for Sunday’s game against the New Orleans Saints, coach Kyle Shanahan said Wednesday.

On Friday, Shanahan had expressed some optimism that Mostert, who is on injured reserve with a high ankle sprain and is eligible to return this week, would be able to practice in some capacity. But that hasn’t been the case, and, with the team’s bye set for next week, Mostert’s return will have to wait.

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“[He] won’t play this week,” Shanahan said. “Hopeful to have him back for the Rams.”

The Niners travel to Los Angeles for a rematch with the Rams on Nov. 29.

Receiver Deebo Samuel, who has missed the past two games with a hamstring injury, also did not practice Wednesday, though Shanahan said he would be reevaluated Thursday, leaving

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