5:59 PM ET

ESPN.com staff

We’re through Week 1 of the NFL preseason and injuries already are taking their toll across the league. First-round picks for Tennessee and Tampa Bay have been unable to practice. Pro Bowl receivers in Seattle and Pittsburgh have had issues. And Washington lost its projected top running back for the season.

Here are the biggest injuries of training camp and preseason so far, the prognosis for those players and who could replace them (in no particular order):

Running back Derrius Guice (torn ACL)

Prognosis: The Redskins anticipated Guice providing big plays, but they will now turn to a running back by committee, with Rob Kelley and Samaje Perine on first and second down and Chris Thompson on third. It’s the same group as last season. Kelley and Perine both have looked quicker in camp, but neither has yet shown he can be a full-time lead back. — John Keim

Wide receiver Antonio Brown (right hip/quad strain)

Prognosis: Brown, who missed four days of practice last week after the team sent him back to Pittsburgh for evaluation, practiced in full Saturday and looked like his explosive self, beating several corners in one-on-ones. Steeler

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