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Bosa, who was voted to the Pro Bowl for the third time earlier this week, will miss his third game of the season. He was inactive for the Nov. 8 game against Las Vegas and Nov. 15 contest at Miami due to a concussion.
The Chargers (5-9) have also ruled out defensive tackle Uchenna Nwosu because of a knee injury.
Pro Bowl wide receiver Keenan Allen, second in the AFC with 100 receptions, is questionable because of a hamstring strain.