Colts rule out Leonard, Castonzo vs. Browns

2:29 PM ET

INDIANAPOLIS — The Colts will be missing two of their most important players on offense and defense in their biggest game of the season at Cleveland this weekend.

Starting left tackle Anthony Castonzo and All-Pro linebacker Darius Leonard have been officially ruled out for Sunday’s game against the Browns, coach Frank Reich said Friday.

Castonzo and Leonard suffered rib and groin injuries, respectively, in the Colts’ win at Chicago in Week 4. Leonard missed the second half of the game against the Bears due to the injury.

Neither Castonzo or Leonard practiced this week. Reich did not give a timetable on when he expects Leonard and Castonzo to return. After playing at Cleveland, the Colts host Cincinnati in Week 6 before having a bye in Week 7.

Colts left tackle Frank Castonzo is dealing with a rib injury. Scott Winters/Icon Sportswire

Not having Castonzo ends a string of 22 straight starts starts by the Colts’ offensive lineman, which includes two playoff games.

Le’Raven Clark will start at left tackle and have the challenge of trying to slow Browns pass-rusher Myles Garrett, who is tied for the league high in sacks with five this season.

“With Myles Garrett and

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