Injuries erase 49ers' margin for error

7:46 PM ET

Given the names that dot their lengthy injured reserve list, the San Francisco 49ers will enter just about every game the rest of this season at a disadvantage when it comes to firepower.

That alone makes winning games — especially on the road against an NFC contender like the New Orleans Saints — a difficult proposition. It also means the 49ers aren’t able to overcome the kind of self-inflicted errors they made Sunday.

Absent the likes of George Kittle, Nick Bosa, Raheem Mostert, Deebo Samuel, Jimmy Garoppolo and Richard Sherman, the margin for error for these Niners is razor thin. That point was hammered home Sunday against the Saints as the Niners fell 27-13 in a game that was there for the taking.

Nick Mullens was 24-of-38 for 247 yards with one touchdown and two interceptions. AP Photo/Brett Duke

The first quarter couldn’t have gone much better for the Niners, who jumped out to a 10-0 lead and held the ball for more than 13 minutes. If there was a blueprint for an upset, the 49ers were following it. Alas, the 49ers couldn’t get out of their own way.

Holding a 10-3 lead and set to get the

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